KMID : 0369820130430030205
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Jorunal of Korean Pharmaceutical Sciences 2013 Volume.43 No. 3 p.205 ~ p.213
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Enhanced dissolution rate of celecoxib using PVP and/or HPMC-based solid dispersions prepared by spray drying method
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Lee Jung-Hwan
Kim Min-Jeong Yoon Hye-On Shim Cho-Rok Ko Hyun-Ah Cho Sun-Ah Lee Dong-Won Khang Gil-Son
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Abstract
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Celecoxib with low solubility and high permeability (BCS class II) in water is a non-steroidal anti-inflammatory drug used in the treatment of pain and inflammation, associated with rheumatoid arthritis, and several other inflammatory disorders. Also, it is a selective cyclooxygenase 2 inhibitor with low water solubility and high crystallinity. The objective of this study was to improve dissolution rate of celecoxib which was water-insoluble drug. Solid dispersions were prepared by spray drying as the solvent evaporation method. The dissolution behavior of solid dispersions was compared with Celebrex¢ç (Pfizer) as a control group in simulated gastric juice (pH 1.2, 0.5 % SLS. The characterization of the prepared solid dispersions is analyzed by scanning electron microscope, powder X-ray diffractometer, Fourier transform infrared spectroscopy and reverse phase-high performance liquid chromatography The best formulation was SD 8 in this study. It was the cumulative release of 97 % at 120 min. This study suggests that the solubility and bioavailability of poorly water-soluble celecoxib improved through the prepared solid dispersions by spray drying method.
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KEYWORD
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Amorphous, Celecoxib, Encapsulation, Solid dispersion, Spray drying, Water-soluble polymer
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